Las tasas de conversión fueron similares entre los dos grupos de tratamientos para pacientes con aleteo auricular. Los pacientes con fibrilación auricular que habían recibido dofetilida y magnesio tenían tasas más altas de cardioversión con éxito comparados con los que habían recibido sólo dofetilida. No se encontraron estudios con amiodarona. Resultados: Se identificaron 1 estudio de dofetilida y 5 estudios de ibutilida. Métodos: Se utilizaron las bases de datos Pubmed y CINAHL con los términos de busca amiodarona, dofetilida, ibutilida, magnesio, fibrilación auricular, conversión, control del ritmo y cardioversión. Objetivo: El objetivo de este artículo es revisar la literatura sobre la eficacia del magnesio adicionado a los anti-arrítmicos de clase III, específicamente amiodarona, ibutilida y dofetilida para la cardioversión de la fibrilación auricular. El magnesio posee propiedades intrínsecas anti-arrítmicas y potencialmente puede aumentar la eficacia de los anti-arrítimicos de clase III cuando se usa concomitantemente. Los anti-arrítmicos clase III como la dofetilida, ibutilida y amiodarona están indicados para el control del ritmo. La fibrilación auricular es una arritmia cardiaca frecuente, y se ha identificado como una carga financiera significativa. Dose ranging studies should be conducted in the future to establish the optimal dose and duration of therapy as well as the optimal serum magnesium concentration in order for the clinician to manage and monitor patients appropriately. ![]() ![]() Therefore, differences in baseline demographics may have influenced the results.Ĭonclusion: Magnesium may be used as adjunct for dofetilide and ibutilide due to potential improved efficacy and minimal toxicity. However, only 2 ibutilide studies and 1 dofetilide study reported baseline characteristics such as left atrial size, history of heart failure, and duration of atrial fibrillation, which are significant predictors of successful cardioversion. Patients who received magnesium had shorter corrected QT intervals and smaller increase in corrected QT interval from baseline.Ĭompare to previous studies, studies included in this review had higher conversion rates for dofetilide and ibutilide as well as dofetilide and magnesium or ibutilide and magnesium combination therapies. Adverse effects of magnesium were mild and included flushing, tingling, and dizziness. ![]() Higher doses of magnesium (4 g) were associated with improved outcomes. One study showed that addition of magnesium did not improve efficacy of ibutilide. Conversion rates were similar for patients with atypical atrial flutter. As for ibutilide, 4 studies have shown that the addition of magnesium significantly increases conversion rates for patients with atrial fibrillation or typical atrial flutter. Conversion rates were similar between the 2 treatment groups for patients with atrial flutter. Patients with atrial fibrillation who received dofetilide and magnesium had higher rates of successful cardioversion as compared to those who only received dofetilide. Results: One study on dofetilide and 5 studies on ibutilide were identified. Methods: Databases Pubmed and CINAHL are utilized along with the search terms amiodarone, dofetilide, ibutlide, magnesium, atrial fibrillation, conversion, rhythm control, and cardioversion. Objective: The purpose of this article is to review the literature on the efficacy of magnesium in addition to Class III antiarrhythmics, specifically amidarone, ibutilide, and dofetilide for the cardioversion of atrial fibrillation. Magnesium may possess intrinsic antiarrhythmic properties, and may potentially increase the efficacy of class III antiarrhythmics when used concomitantly. Class III antiarrhythmics such as dofetilide, ibutilide, and amiodarone are indicated for rhythm control. Brooklyn, NY (United States).Ītrial fibrillation is a common cardiac arrhythmia, and has been a significant financial burden. Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University. ![]() Assistant Professor of Pharmacy Practice. Efficacy of class III antiarrhythmics and magnesium combination therapy for atrial fibrillationĮficacia del tratamiento de combinación de anti-arrítmicos clase III y magnesio para la fibrilación auricular
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